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Active Ingredient: Metronidazole

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Flagyl is an antibacterial drug with an antiprotozoal effect.

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Flagyl 400mg

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Flagyl drug description

Unfortunately, infectious diseases are a problem that every person faces from time to time. And antimicrobials come to the rescue in such cases. Today, many patients are interested in questions about what the Flagyl drug is. Instructions for use of the drug, contraindications and possible side effects will be considered in the article.

This medicine is available in three forms - these are tablets, vaginal suppositories and gel for external use. The tablets have a rounded shape and are coated with a resistant shell, the color of which, depending on the manufacturer, may be white or yellowish. The main active ingredient is metronidazole - each tablet contains 250 mg of this substance. Naturally, other chemical compounds are also used in the production. In particular, magnesium stearate, wheat starch and povidone are present in the preparation. The hard shell of the tablets is made from macrogol and hypromellose.

Pharmacological properties of the drug

Of course, the main properties of the drug are provided by the presence of metronidazole, which is a derivative of 5-nitroimidazole, in its composition. This substance interacts with the DNA of pathogenic microorganisms, blocks the synthesis of nucleic acids, which, accordingly, leads to the death of pathogens of certain diseases.

So what infection can be eliminated with the help of the drug “Flagyl”? The instruction indicates that it is active against certain varieties of Trichomonas. In addition, some gram-negative anaerobes, as well as protozoa, including amoebas, are sensitive to the drug.

The drug “Flagyl” (tablets, gel and vaginal suppositories) is characterized by high bioavailability. Almost 80% of the active substance is absorbed by the walls of the digestive tract within an hour after use. Together with the blood stream, metronidazole enters almost all tissues of the human body, including the kidneys, lungs, skin, liver, as well as cerebrospinal fluid, semen, bile, saliva and vaginal secretions. About 40-70% of the active substance is excreted through the kidneys, both in its original form and in the form of metabolites.

The drug Flagyl (tablets): instructions for use

Of course, the dosage and duration of therapy are determined by the attending physician, since they depend on the age of the patient, the form of his disease, as well as the general condition of the body.

  • For example, with intestinal amoebiasis, the daily dose of metronidazole is 1500 mg - this amount of the drug must be divided into three doses. The daily dose for children 10-15 years old is 500 mg.
  • Extraintestinal forms of amoebiasis require a higher amount of medication - 2500 mg per day, divided into three doses.
  • In the presence of trichomoniasis, patients are first prescribed a single dose of 2 g, after which patients take another tablet for another ten days, one tablet twice a day.
  • In the presence of anaerobic infections, adults are advised to take 500 mg of the drug three times a day.
  • In the presence of Helicobacter pylori, Flagyl is used as part of complex therapy. In such cases, patients take 500 mg of the drug 3, and sometimes 4 times a day.
  • The scheme for surgical interventions looks a little different. In the first 3-4 days, patients take 750-1500 mg of the drug per day. In the future, patients are recommended to take one tablet three times a day for another week.

In any case, it should be understood that this medicine is not intended for long-term therapy - the longer the patient takes it, the higher the likelihood of developing serious side effects. In no case should you deviate from the scheme chosen by the doctor.

Precautions during therapy

It should be understood that metronidazole is a fairly powerful tool, therefore, therapy can be associated with some danger. To begin with, it should be noted that this active component can react with alcohol, leading to side effects such as severe vomiting, sensation of fever and tachycardia. That is why during therapy it is categorically contraindicated to drink alcohol or medicines containing ethyl alcohol.

People ask another important question: "Is it possible to drive a car after taking the drug" Flagyl "?" Instructions for use indicate the main side effects from treatment, in particular, visual impairment and dizziness. Thus, it is worth giving up driving or working with other dangerous mechanisms during therapy.

Metronidazole is intended for short-term treatment. In the event that the patient needs a longer reception, he should be under the constant supervision of medical personnel.

If we are talking about the treatment of trichomoniasis, then both partners should undergo therapy at once. By the way, during treatment, it is best to refuse sexual intercourse in order to exclude the possibility of re-infection.

Feasible side effects

Like other antibacterial agents created on the basis of metronidazole, the drug “Flagyl” can cause adverse reactions. Some disorders are quite harmless, while some are dangerous to health. Therefore, it is worth familiarizing yourself with the main list of adverse reactions:

  • First of all, it is worth mentioning that therapy can be associated with an allergic reaction, the symptoms of which are urticaria, rash, skin hyperemia, itching, and in more severe cases, anaphylactic shock and angioedema.
  • Quite often, patients complain of disturbances in the digestive system, namely nausea, vomiting, pain in the stomach, diarrhea, constipation, the appearance of an unpleasant metallic taste in the mouth, as well as increased dry mouth, decreased appetite (sometimes even anorexia). Against the background of therapy, glossitis, pancreatitis, stomatitis can develop.
  • In some cases, reactions from the nervous system, in particular dizziness and headaches, are observed. Encephalopathy, aseptic meningitis, and sensory neuropathy are much less common.
  • Patients sometimes have mental disorders. For example, some of the patients complain of increased irritability, constant irritability, and problems with sleep. Against the background of therapy, hallucinations, confusion, and depressive states may appear.
  • Sometimes patients complain of vision problems, in particular myopia and diplodia.
  • Side effects can also include a change in the color of urine, cystitis, candidiasis, enuresis.
  • In some cases, while taking the drug, nasal congestion, constant weakness, and febrile conditions appear.

It should be noted immediately that in most cases all side effects are reversible - with the timely termination of therapy, the disorders go away on their own. Therefore, if you notice any serious manifestations or worsening of well-being, be sure to tell your doctor. Perhaps the specialist only needs to adjust the dose of the drug or choose another, safer drug with a similar effect on the pathogenic microflora.

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